Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/20.500.12222/165
Título : Dopaminergic neurotransmission dysfunction induced by amyloid-? transforms cortical long-term potentiation into long-term depression and produces memory impairment
Autor(es) : Kioko Guzmán-Ramos, 0000-0002-5180-4127Federico Bermudez_Rattoni, 0000-0003-2056-6119
Autor(es) sin ID: Moreno Castilla, PerlaRodriguez Durán, Luis F.Bárcenas Femat, AlejandroEscobar, Martha L.
Fecha de publicación : 2016
Tipo de resultado Científico: preprint
Palabras clave: Amyloid-beta; Alzheimer's disease; Long-term depression; Long-term potentiation; Dopamine; Recognition memory impairment
Descripción : Alzheimer's disease (AD) is a neurodegenerative condition manifested by synaptic dysfunction and memory loss, but the mechanisms underlying synaptic failure are not entirely understood. Although dopamine is a key modulator of synaptic plasticity, dopaminergic neurotransmission dysfunction in AD has mostly been associated to noncognitive symptoms. Thus, we aimed to study the relationship between dopaminergic neurotransmission and synaptic plasticity in AD models. We used a transgenic model of AD (triple-transgenic mouse model of AD) and the administration of exogenous amyloid-β (Aβ) oligomers into wild type mice. We found that Aβ decreased cortical dopamine levels and converted in vivo long-term potentiation (LTP) into long-term depression (LTD) after high-frequency stimulation delivered at basolateral amygdaloid nucleus–insular cortex projection, which led to impaired recognition memory. Remarkably, increasing cortical dopamine and norepinephrine levels rescued both high-frequency stimulation -induced LTP and memory, whereas depletion of catecholaminergic levels mimicked the Aβ-induced shift from LTP to LTD. Our results suggest that Aβ-induced dopamine depletion is a core mechanism underlying the early synaptopathy and memory alterations observed in AD models and acts by modifying the threshold for the induction of cortical LTP and/or LTD.
Editor: Universidad Autónoma Metropolitana. Unidad Lerma
URI : http://hdl.handle.net/20.500.12222/165
Condiciones de licencia: http://creativecommons.org/licenses/by-nc-nd/4.0/
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