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Título : Exogenous oxytocin reduces signs of sickness behavior and modifies heart rate fluctuations of endotoxemic rats
Autor(es) : Gustavo Pacheco-Lopez, 0000-0002-3458-197X
Autor(es) sin ID: Reyes Lagos, José JavierHadamitzky, MartinPeña Castillo, Miguel ÁngelEcheverría Arjonilla, Juan CarlosBösche, KatharinaLückemann, LauraSchedlowski, Manfred
Fecha de publicación : 2015
Tipo de resultado Científico: article
Palabras clave: Heart Rate Variability; Sickness Behavior; Autonomic Activity; Anti-Inflammatory Cholinergic; Pathway; Oxytocin; LPS
Descripción : Besides the well-known roles of oxytocin on birth, maternal bonding, and lactation, recent evidence shows that this hypothalamic hormone possesses cardioprotective, anti-inflammatory and parasympathetic neuromodulation properties. In this study, we explore the heart rate fluctuations (HRF) in an endotoxemic rodent model that was accompanied by the administration of exogenous oxytocin. The assessment of HRF has been widely used as an indirect measure of the cardiac autonomic function. In this context, adult male Dark Agouti rats were equipped with a telemetric transmitter to continuously and remotely measure the electrocardiogram, temperature, and locomotion. In a between-subjects experimental design, rats received the following peripheral treatment: saline solution as a vehicle (V); lipopolysaccharide (LPS); oxytocin (Ox); lipopolysaccharide + oxytocin (LPS + Ox). Linear and non-linear parameters of HRF were estimated starting 3 h before to 24 h after treatments. Our results showed that exogenous oxytocin does not modify by itself the HRF of oxytocin-treated rats in comparison to vehicle-treated rats. However, in animals undergoing endotoxemia it: a) provokes a less anticorrelated pattern in HRF, b) decreased mean heart rate, c) moderated the magnitude and duration of the LPS-induced hyperthermia, and d) increased locomotion, up to 6 h after the LPS injection. The less anticorrelated pattern in the HRF and decreased mean heart rate may reflect a cardiac pacemaker coupling with cholinergic influences mediated by oxytocin during LPS-induced endotoxemia. Finally, the anti-lethargic and long-term temperature moderating effects of the administration of oxytocin during endotoxemia could be a consequence of the systemic anti-inflammatory properties of oxytocin
Editor: Elsevier
International Behavioral Neuroscience Society
URI : http://hdl.handle.net/20.500.12222/179
Condiciones de licencia: https://www.elsevier.com/about/our-business/policies/sharing
Se autoriza la reproducción total o parcial de los textos aquí publicados siempre y cuando sea sin fines de lucro y se cite la fuente completa y la dirección electrónica de la publicación.
Fuente: Physiology and Behavior, vol.165 (2015)
ISSN: 0031-9384
Aparece en las colecciones: Artículos Científicos

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