Stem cell models : a guide to understand and mitigate aging?
Stem cell models : a guide to understand and mitigate aging?
Date
2017
Authors
Regina Brunauer, 0000-0001-9384-5501
Silvestre Alavez, 0000-0002-9220-0696
Journal Title
Journal ISSN
Volume Title
Publisher
Universidad Autónoma Metropolitana. Unidad Lerma
Abstract
Description
Aging is studied either on a systemic level using life span and health span of animal models, or on the cellular level using replicative life span of yeast or mammalian cells. While useful in identifying general and conserved pathways of aging, both approaches provide only limited information about cell-type specific causes and mechanisms of aging. Stem cells are the regenerative units of multicellular life, and stem cell aging might be a major cause for organismal aging. Using the examples of hematopoietic stem cell aging and human pluripotent stem cell models, we propose that stem cell models of aging are valuable for studying tissue-specific causes and mechanisms of aging and can provide unique insights into the mammalian aging process that may be inaccessible in simple model organisms.
Keywords
MEDICINA Y CIENCIAS DE LA SALUD