New insights on retrieval-induced and ongoing memory consolidation : lessons from arc

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dc.audience researchers es_MX
dc.contributor.author Kioko Guzmán-Ramos, 0000-0002-5180-4127
dc.contributor.author Jean-Pascal Morin, 0000-0001-8221-4982
dc.contributor.other Bermudez Rattoni, Federico
dc.coverage GB es_MX
dc.date.accessioned 2018-05-30T21:02:08Z
dc.date.available 2018-05-30T21:02:08Z
dc.date.issued 2015
dc.description The mainstream view on the neurobiological mechanisms underlying memory formation states that memory traces reside on the network of cells activated during initial acquisition that becomes active again upon retrieval (reactivation). These activation and reactivation processes have been called “conjunctive trace.” This process implies that singular molecular events must occur during acquisition, strengthening the connection between the implicated cells whose synchronous activity must underlie subsequent reactivations. The strongest experimental support for the conjunctive trace model comes from the study of immediate early genes such as c-fos, zif268, and activity-regulated cytoskeletal-associated protein. The expressions of these genes are reliably induced by behaviorally relevant neuronal activity and their products often play a central role in long-term memory formation. In this review, we propose that the peculiar characteristics of Arc protein, such as its optimal expression after ongoing experience or familiar behavior, together with its versatile and central functions in synaptic plasticity could explain how familiarization and recognition memories are stored and preserved in the mammalian brain. es_MX
dc.format application/pdf es_MX
dc.identificador.materia 2 es_MX
dc.identifier.other http://dx.doi.org/10.1155/2015/184083
dc.identifier.uri http://hdl.handle.net/20.500.12222/38
dc.language eng es_MX
dc.publisher Hindawi Publishing Corporation es_MX
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights.license info:eu-repo/semantics/openAccess es_MX
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ es_MX
dc.source.other Neural Plasticity, vol.2015 (2015) es_MX
dc.source.other ISSN: 2090-5904 es_MX
dc.subject BIOLOGÍA Y QUÍMICA es_MX
dc.subject.keywords Memory Formation es_MX
dc.subject.keywords ARC Protein es_MX
dc.subject.keywords Synapses es_MX
dc.subject.keywords Neuronal Network es_MX
dc.title New insights on retrieval-induced and ongoing memory consolidation : lessons from arc es_MX
dc.type article es_MX
dc.type.version info:eu-repo/semantics/publishedVersion es_MX
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