Exogenous oxytocin reduces signs of sickness behavior and modifies heart rate fluctuations of endotoxemic rats

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dc.audience researchers es_MX
dc.contributor.author Gustavo Pacheco-Lopez, 0000-0002-3458-197X
dc.contributor.other Reyes Lagos, José Javier
dc.contributor.other Hadamitzky, Martin
dc.contributor.other Peña Castillo, Miguel Ángel
dc.contributor.other Echeverría Arjonilla, Juan Carlos
dc.contributor.other Bösche, Katharina
dc.contributor.other Lückemann, Laura
dc.contributor.other Schedlowski, Manfred
dc.coverage SZ es_MX
dc.date.accessioned 2018-06-28T01:03:28Z
dc.date.available 2018-06-28T01:03:28Z
dc.date.issued 2015
dc.description Besides the well-known roles of oxytocin on birth, maternal bonding, and lactation, recent evidence shows that this hypothalamic hormone possesses cardioprotective, anti-inflammatory and parasympathetic neuromodulation properties. In this study, we explore the heart rate fluctuations (HRF) in an endotoxemic rodent model that was accompanied by the administration of exogenous oxytocin. The assessment of HRF has been widely used as an indirect measure of the cardiac autonomic function. In this context, adult male Dark Agouti rats were equipped with a telemetric transmitter to continuously and remotely measure the electrocardiogram, temperature, and locomotion. In a between-subjects experimental design, rats received the following peripheral treatment: saline solution as a vehicle (V); lipopolysaccharide (LPS); oxytocin (Ox); lipopolysaccharide + oxytocin (LPS + Ox). Linear and non-linear parameters of HRF were estimated starting 3 h before to 24 h after treatments. Our results showed that exogenous oxytocin does not modify by itself the HRF of oxytocin-treated rats in comparison to vehicle-treated rats. However, in animals undergoing endotoxemia it: a) provokes a less anticorrelated pattern in HRF, b) decreased mean heart rate, c) moderated the magnitude and duration of the LPS-induced hyperthermia, and d) increased locomotion, up to 6 h after the LPS injection. The less anticorrelated pattern in the HRF and decreased mean heart rate may reflect a cardiac pacemaker coupling with cholinergic influences mediated by oxytocin during LPS-induced endotoxemia. Finally, the anti-lethargic and long-term temperature moderating effects of the administration of oxytocin during endotoxemia could be a consequence of the systemic anti-inflammatory properties of oxytocin es_MX
dc.format application/pdf es_MX
dc.identificador.materia 3 es_MX
dc.identifier.other http://dx.doi.org/10.1016/j.physbeh.2016.07.013
dc.identifier.uri http://hdl.handle.net/20.500.12222/179
dc.language eng es_MX
dc.publisher Elsevier es_MX
dc.publisher International Behavioral Neuroscience Society es_MX
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights.license info:eu-repo/semantics/restrictedAccess es_MX
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ es_MX
dc.source.other Physiology and Behavior, vol.165 (2015) es_MX
dc.source.other ISSN: 0031-9384 es_MX
dc.subject MEDICINA Y CIENCIAS DE LA SALUD es_MX
dc.subject.keywords Heart Rate Variability es_MX
dc.subject.keywords Sickness Behavior es_MX
dc.subject.keywords Autonomic Activity es_MX
dc.subject.keywords Anti-Inflammatory Cholinergic es_MX
dc.subject.keywords Pathway es_MX
dc.subject.keywords Oxytocin es_MX
dc.subject.keywords LPS es_MX
dc.title Exogenous oxytocin reduces signs of sickness behavior and modifies heart rate fluctuations of endotoxemic rats es_MX
dc.type article es_MX
dc.type.version info:eu-repo/semantics/publishedVersion es_MX
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