Memory trace reactivation and behavioral response during retrieval are differentially modulated by amygdalar glutamate receptors activity: Interaction between amygdala and insular cortex

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dc.audience researchers es_MX
dc.contributor.author Daniel Osorio-Gómez, 0000-0001-8325-8506
dc.contributor.author Federico Bermudez_Rattoni, 0000-0003-2056-6119
dc.contributor.author Kioko Guzmán-Ramos, 0000-0002-5180-4127
dc.coverage US es_MX
dc.date.accessioned 2018-06-26T06:10:11Z
dc.date.available 2018-06-26T06:10:11Z
dc.date.issued 2016
dc.description The insular cortex (IC) is required for conditioned taste aversion (CTA) retrieval. However, it remains unknown which cortical neurotransmitters levels are modified upon CTA retrieval. Using in vivo microdialysis, we observed that there were clear elevations in extracellular glutamate, norepinephrine, and dopamine in and around the center of the gustatory zone of the IC during CTA retrieval. Additionally, it has been reported that the amygdala–IC interaction is highly involved in CTA memory establishment. Therefore, we evaluated the effects of infusions of an AMPA receptor antagonist (CNQX) and a NMDA receptor antagonist (APV) into the amygdala on CTA retrieval and IC neurotransmitter levels. Infusion of APV into the amygdala impaired glutamate augmentation within the IC, whereas dopamine and norepinephrine levels augmentation persisted and a reliable CTA expression was observed. Conversely, CNQX infusion into the amygdala impaired the aversion response, as well as norepinephrine and dopamine augmentations in the IC. Interestingly, CNQX infusion did not affect glutamate elevation in the IC. To evaluate the functional meaning of neurotransmitters elevations within the IC on CTA response, we infused specific antagonists for the AMPA, NMDA, D1, and β-adrenergic receptor before retrieval. Results showed that activation of AMPA, D1, and β-adrenergic receptors is necessary for CTA expression, whereas NMDA receptors are not involved in the aversion response. es_MX
dc.format application/pdf es_MX
dc.identificador.materia 3 es_MX
dc.identifier.other http://dx.doi.org/10.1101/lm.042895.116
dc.identifier.uri http://hdl.handle.net/20.500.12222/149
dc.language eng es_MX
dc.publisher Cold Spring Harbor Laboratory Press es_MX
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights.license info:eu-repo/semantics/openAccess es_MX
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ es_MX
dc.source.other Learning & Memory, vol.24 (2016) es_MX
dc.source.other ISSN: 1072-0502 es_MX
dc.subject MEDICINA Y CIENCIAS DE LA SALUD es_MX
dc.subject.keywords Corteza insular es_MX
dc.subject.keywords Microdiálisis es_MX
dc.subject.keywords Neurotransmisores corticales es_MX
dc.subject.keywords Glutamato extracelular es_MX
dc.subject.keywords Norepinefrina es_MX
dc.subject.keywords Dopamina es_MX
dc.subject.keywords Amígdala-IC es_MX
dc.title Memory trace reactivation and behavioral response during retrieval are differentially modulated by amygdalar glutamate receptors activity: Interaction between amygdala and insular cortex es_MX
dc.type article es_MX
dc.type.version info:eu-repo/semantics/publishedVersion es_MX
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