Conditioning immune and endocrine parameters in humans : a systematic review

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dc.audience researchers es_MX
dc.contributor.author Gustavo Pacheco-Lopez, 0000-0002-3458-197X
dc.contributor.other Tekampe, Judith
dc.contributor.other Van Middendorp, Henriët
dc.contributor.other Meeuwis, Stefanie H.
dc.contributor.other Van Leusden, Jelle W.R.
dc.contributor.other Hermus, A.R.M.M
dc.contributor.other Evers, A.W.M
dc.coverage IT es_MX
dc.date.accessioned 2018-05-30T22:53:35Z
dc.date.available 2018-05-30T22:53:35Z
dc.date.issued 2017
dc.description Background: Conditioned pharmacological effects may provide relevant clinical opportunities to improve treatment for patients with a variety of conditions. The aim of this systematic review was to create an overview of studies in this field of research and to investigate whether specific characteristics of the study design make for successful conditioning. Methods: The protocol of this review was registered in Prospero (PROSPERO 2015: CRD42015024148). A systematic literature search was conducted in the databases PubMed, Embase, and PsychInfo. Studies were included if they were placebo-controlled trials in humans in which the effects of a pharmacological agent on immune or endocrine outcomes (e.g., interleukin-2 and cortisol) were conditioned, using a specific conditioned stimulus. The risk of bias of each study was assessed using the Cochrane risk-of-bias tool. Results: The final selection included 16 studies. Overall, those studies indicate that conditioning of immunosuppression, conditioning of allergic responses, and conditioning of insulin and glycemic responses is possible. Regarding immunostimulants, antiallergic effects, and cortisol conditioning, the preliminary results are promising, but additional studies are needed. Conclusions: This systematic review shows classical conditioning of immune and endocrine responses for various pharmaceutical substances. The studies reviewed here indicate that the number of acquisition and evocation sessions, and characteristics of the unconditioned and conditioned stimuli, are important determinants of the effectiveness of pharmacological conditioning on immune and endocrineparameters. In the future, conditioned pharmacological effects may be used clinically as adjunct therapy in various patient populations. es_MX
dc.format application/pdf es_MX
dc.identificador.materia 3 es_MX
dc.identifier.other https://doi.org/10.1159/000449470
dc.identifier.uri http://hdl.handle.net/20.500.12222/40
dc.language eng es_MX
dc.publisher Karger Publishers es_MX
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights.license info:eu-repo/semantics/openAccess es_MX
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ es_MX
dc.source.other Psychotherapy and Psychosomatics (2) vol.86 (2017) es_MX
dc.source.other ISSN: 0033-3190 es_MX
dc.subject MEDICINA Y CIENCIAS DE LA SALUD es_MX
dc.subject.keywords Pharmacological Conditioning es_MX
dc.subject.keywords Associative Learning es_MX
dc.subject.keywords Placebo effect es_MX
dc.subject.keywords Placebo es_MX
dc.subject.keywords Endocrine System es_MX
dc.subject.keywords Immune System es_MX
dc.subject.keywords Allergy es_MX
dc.title Conditioning immune and endocrine parameters in humans : a systematic review es_MX
dc.type article es_MX
dc.type.version info:eu-repo/semantics/publishedVersion es_MX
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