Stem cell models : a guide to understand and mitigate aging?

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dc.audience researchers es_MX
dc.contributor.author Regina Brunauer, 0000-0001-9384-5501
dc.contributor.author Silvestre Alavez, 0000-0002-9220-0696
dc.contributor.other Kennedy, Brian
dc.coverage MX es_MX
dc.date.accessioned 2018-06-27T00:43:48Z
dc.date.available 2018-06-27T00:43:48Z
dc.date.issued 2017
dc.description Aging is studied either on a systemic level using life span and health span of animal models, or on the cellular level using replicative life span of yeast or mammalian cells. While useful in identifying general and conserved pathways of aging, both approaches provide only limited information about cell-type specific causes and mechanisms of aging. Stem cells are the regenerative units of multicellular life, and stem cell aging might be a major cause for organismal aging. Using the examples of hematopoietic stem cell aging and human pluripotent stem cell models, we propose that stem cell models of aging are valuable for studying tissue-specific causes and mechanisms of aging and can provide unique insights into the mammalian aging process that may be inaccessible in simple model organisms. es_MX
dc.format text/pdf es_MX
dc.identificador.materia 3 es_MX
dc.identifier.other http://dx.doi.org/10.1159/000449501
dc.identifier.uri http://hdl.handle.net/20.500.12222/162
dc.language eng es_MX
dc.publisher Universidad Autónoma Metropolitana. Unidad Lerma es_MX
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights.license info:eu-repo/semantics/openAccess es_MX
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ es_MX
dc.subject MEDICINA Y CIENCIAS DE LA SALUD es_MX
dc.subject.keywords Reprogramming es_MX
dc.subject.keywords Stem cells es_MX
dc.subject.keywords Progeria es_MX
dc.subject.keywords Aging es_MX
dc.title Stem cell models : a guide to understand and mitigate aging? es_MX
dc.type preprint es_MX
dc.type.version info:eu-repo/semantics/publishedVersion es_MX
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