Acarbose improves health and lifespan in aging HET3 mice

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dc.audience researchers es_MX
dc.contributor.author Silvestre Alavez, 0000-0002-9220-0696
dc.contributor.author Martin Javors, 0000-0002-8430-1497
dc.contributor.author moshe levi, 0000-0001-6403-2261
dc.contributor.author Stacey J. Sukoff Rizzo, 0000-0002-1460-8127
dc.contributor.other Harrison, David E.
dc.contributor.other Strong, Randy
dc.contributor.other Astle, Clinton Michael
dc.contributor.other DiGiovanni, John
dc.contributor.other Fernández, Elizabeth
dc.contributor.other Flurkey, Kevin
dc.contributor.other Garrat, Michael
dc.contributor.other Gelfond, Jonathan A. L.
dc.contributor.other Lithgow, Gordon J.
dc.contributor.other Macchiarini, Francesca
dc.contributor.other Nelson, James F.
dc.contributor.other Slaga, Thomas J.
dc.contributor.other Stearns, Tim
dc.contributor.other Wilkinson, John Erby
dc.contributor.other Miller, Richard A.
dc.coverage UK es_MX
dc.date.accessioned 2022-11-30T22:42:41Z
dc.date.available 2022-11-30T22:42:41Z
dc.date.issued 2018
dc.description To follow‐up on our previous report that acarbose (ACA), a drug that blocks postprandial glucose spikes, increases mouse lifespan, we studied ACA at three doses: 400, 1,000 (the original dose), and 2,500 ppm, using genetically heterogeneous mice at three sites. Each dose led to a significant change (by log‐rank test) in both sexes, with larger effects in males, consistent with the original report. There were no significant differences among the three doses. The two higher doses produced 16% or 17% increases in median longevity of males, but only 4% or 5% increases in females. Age at the 90th percentile was increased significantly (8%–11%) in males at each dose but was significantly increased (3%) in females only at1,000 ppm. The sex effect on longevity is not explained simply by weight or fat mass, which were reduced by ACA more in females than in males. ACA at 1,000 ppm reduced lung tumors in males, diminished liver degeneration in both sexes and glomerulosclerosis in females, reduced blood glucose responses to refeeding in males, and improved rotarod performance in aging females, but not males. Three other interventions were also tested: ursolic acid, 2‐(2‐hydroxyphenyl) benzothiazole (HBX), and INT‐767; none of these affected lifespan at the doses tested. The acarbose results confirm and extend our original report, prompt further attention to the effects of transient periods of high blood glucose on aging and the diseases of aging, including cancer, and should motivate studies of acarbose and other glucose‐control drugs in humans. es_MX
dc.format application/pdf es_MX
dc.identificador.materia 3 es_MX
dc.identifier.uri http://hdl.handle.net/20.500.12222/320
dc.language eng es_MX
dc.publisher Wiley Open Access es_MX
dc.publisher Anatomical Society of Great Britain and Ireland es_MX
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights.license info:eu-repo/semantics/openAccess es_MX
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.source.other Aging cell. (2) vol.18 (2019) es_MX
dc.source.other ISSN: 1474-9718 es_MX
dc.subject MEDICINA Y CIENCIAS DE LA SALUD es_MX
dc.subject.keywords Acarbose es_MX
dc.subject.keywords Heterogeneous mice es_MX
dc.subject.keywords Health measures es_MX
dc.subject.keywords Lifespan es_MX
dc.title Acarbose improves health and lifespan in aging HET3 mice es_MX
dc.type article es_MX
dc.type.uri https://doi.org/10.1111/acel.12898 es_MX
dc.type.version info:eu-repo/semantics/publishedVersion es_MX
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