Switching adolescent high-fat diet to adult control diet restores neurocognitive alterations

dc.audience researchers es_MX
dc.contributor.author Gustavo Pacheco-Lopez, 0000-0002-3458-197X
dc.contributor.other Boitard, Chloé
dc.contributor.other ParkesL, Shauna L
dc.contributor.other Cavaroc, Amandine
dc.contributor.other Tantot, Frédéric
dc.contributor.other Nathalie, Castanon
dc.contributor.other Layé, Sophie
dc.contributor.other Tronel, Sophie
dc.contributor.other Coutureau, Etienne
dc.contributor.other Ferreira, Guillaume
dc.coverage PT es_MX
dc.date.accessioned 2018-05-30T22:41:17Z
dc.date.available 2018-05-30T22:41:17Z
dc.date.issued 2016
dc.description In addition to metabolic and cardiovascular disorders, obesity is associated with adverse cognitive and emotional outcomes. Its growing prevalence in adolescents is particularly alarming since this is a period of ongoing maturation for brain structures (including the hippocampus and amygdala) and for the hypothalamic-pituitary-adrenal (HPA) stress axis, which is required for cognitive and emotional processing. We recently demonstrated that adolescent, but not adult, high-fat diet (HF) exposure leads to impaired hippocampal function and enhanced amygdala function through HPA axis alteration (Boitard et al., 2012, 2014, 2015). Here, we assessed whether the effects of adolescent HF consumption on brain function are permanent or reversible. After adolescent exposure to HF, switching to a standard control diet restored levels of hippocampal neurogenesis and normalized enhanced HPA axis reactivity, amygdala activity and avoidance memory. Therefore, while the adolescent period is highly vulnerable to the deleterious effects of diet-induced obesity, adult exposure to a standarddiet appears sufficient to reverse alterations of brain function. es_MX
dc.format application/pdf es_MX
dc.identificador.materia 3 es_MX
dc.identifier.other https://doi.org/10.3389/fnbeh.2016.00225
dc.identifier.uri http://hdl.handle.net/20.500.12222/39
dc.language eng es_MX
dc.publisher Frontiers Media es_MX
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights.license info:eu-repo/semantics/openAccess es_MX
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ es_MX
dc.source.other Frontiers in Behavioral Neuroscience, vol.10 (2016) es_MX
dc.source.other ISSN: 0735-7044 es_MX
dc.subject MEDICINA Y CIENCIAS DE LA SALUD es_MX
dc.subject.keywords Hippocampus es_MX
dc.subject.keywords Amygdala es_MX
dc.subject.keywords Obesity es_MX
dc.subject.keywords Learning es_MX
dc.subject.keywords Adolescence es_MX
dc.subject.keywords Neurogenesis es_MX
dc.subject.keywords Rat es_MX
dc.title Switching adolescent high-fat diet to adult control diet restores neurocognitive alterations es_MX
dc.type article es_MX
dc.type.version info:eu-repo/semantics/publishedVersion es_MX
Files
Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
000029.pdf
Size:
1.95 MB
Format:
Adobe Portable Document Format
Description:
11 páginas
No Thumbnail Available
Name:
000029.xml
Size:
1.98 MB
Format:
Extensible Markup Language
Description:
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: