Physiological immunological and evolutionary perspectives of labor as an inflammatory process
Physiological immunological and evolutionary perspectives of labor as an inflammatory process
Date
2014
Authors
Gustavo Pacheco-Lopez, 0000-0002-3458-197X
Journal Title
Journal ISSN
Volume Title
Publisher
IOS Press
Abstract
Description
Los mecanismos precisos para el inicio del trabajo de parto a término siguen siendo desconocidos, sin embargo, varios estudios en humanos revelan el papel de las citocinas en el inicio y el mantenimiento del trabajo de parto, mostrando muchas de las características de la inflamación. Los hallazgos recientes sugieren una posible relación entre la actividad del sistema nervioso autónomo (SNA) y la respuesta antiinflamatoria vagal durante el trabajo de parto. Además, el papel de la microbiota vaginal es particularmente importante durante el embarazo porque el dismicrobismo vaginal es uno de los mecanismos más importantes asociados con el parto prematuro. En esta revisión, presentamos evidencia que sugiere que se manifiesta una respuesta antiinflamatoria estéril para atenuar la inflamación excesiva introducida por el parto de bajo riesgo a término, que involucra la acción de una vía colinérgica, mioquinas uterinas o el microbioma vaginal.
The precise mechanisms for the onset of labor at term remain unknown, yet several studies in humans reveal the role of cytokines in the initiation and maintenance of labor, showing many of the hallmarks of inflammation. Recent findings suggest a possible relationship between the activity of the autonomic nervous system (ANS) and the vagal anti-inflammatory response during labor. Furthermore, the role of vaginal microbiota is particularly important during pregnancy because vaginal dismicrobism is one of the most important mechanisms associated with preterm birth. In this review, we present evidence suggesting that a sterile anti-inflammatory response is manifested to attenuate the excessive inflammation introduced by low-risk labor at term, involving either the action of a cholinergic pathway, uterine-like myokines or the vaginal microbiome.
The precise mechanisms for the onset of labor at term remain unknown, yet several studies in humans reveal the role of cytokines in the initiation and maintenance of labor, showing many of the hallmarks of inflammation. Recent findings suggest a possible relationship between the activity of the autonomic nervous system (ANS) and the vagal anti-inflammatory response during labor. Furthermore, the role of vaginal microbiota is particularly important during pregnancy because vaginal dismicrobism is one of the most important mechanisms associated with preterm birth. In this review, we present evidence suggesting that a sterile anti-inflammatory response is manifested to attenuate the excessive inflammation introduced by low-risk labor at term, involving either the action of a cholinergic pathway, uterine-like myokines or the vaginal microbiome.
Keywords
MEDICINA Y CIENCIAS DE LA SALUD