Differential requirement of de novo Arc protein synthesis in the insular cortex and the amygdala for safe and aversive taste long-term memory formation
Differential requirement of de novo Arc protein synthesis in the insular cortex and the amygdala for safe and aversive taste long-term memory formation
Date
2018
Authors
Kioko Guzmán-Ramos, 0000-0002-5180-4127
Jean-Pascal Morin, 0000-0001-8221-4982
Archana Venkataraman, 0000-0002-2991-7395
Federico Bermudez_Rattoni, 0000-0003-2056-6119
Daniel Osorio-Gómez, 0000-0001-8325-8506
Journal Title
Journal ISSN
Volume Title
Publisher
Science Direct
Elsevier
Elsevier
Abstract
Description
Several immediate early genes products are known to be involved in the facilitation of structural and functional modifications at distinct synapses activated through experience. The IEG-encoded protein Arc (activity regulated cytoskeletal-associated protein) has been widely implicated in long-term memory formation and stabilization. In this study, we sought to evaluate a possible role for de novo Arc protein synthesis in the insular cortex (IC) and in the amygdala (AMY) during long-term taste memory formation. We found that acute inhibition of Arc protein synthesis through the infusion of antisense oligonucleotides administered in the IC before a novel taste presentation, affected consolidation of a safe taste memory trace (ST) but spared consolidation of conditioned taste aversion (CTA). Conversely, blocking Arc synthesis within the AMY impaired CTA consolidation but had no effect on ST long-term memory formation. Our results suggest that Arc-dependent plasticity during taste learning is required within distinct structures of the medial temporal lobe, depending on the emotional valence of the memory trace.
Keywords
MEDICINA Y CIENCIAS DE LA SALUD