Differential requirement of de novo Arc protein synthesis in the insular cortex and the amygdala for safe and aversive taste long-term memory formation

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dc.audience researchers es_MX
dc.contributor.author Kioko Guzmán-Ramos, 0000-0002-5180-4127
dc.contributor.author Jean-Pascal Morin, 0000-0001-8221-4982
dc.contributor.author Archana Venkataraman, 0000-0002-2991-7395
dc.contributor.author Federico Bermudez_Rattoni, 0000-0003-2056-6119
dc.contributor.author Daniel Osorio-Gómez, 0000-0001-8325-8506
dc.coverage NL es_MX
dc.date.accessioned 2022-11-30T22:57:53Z
dc.date.available 2022-11-30T22:57:53Z
dc.date.issued 2018
dc.description Several immediate early genes products are known to be involved in the facilitation of structural and functional modifications at distinct synapses activated through experience. The IEG-encoded protein Arc (activity regulated cytoskeletal-associated protein) has been widely implicated in long-term memory formation and stabilization. In this study, we sought to evaluate a possible role for de novo Arc protein synthesis in the insular cortex (IC) and in the amygdala (AMY) during long-term taste memory formation. We found that acute inhibition of Arc protein synthesis through the infusion of antisense oligonucleotides administered in the IC before a novel taste presentation, affected consolidation of a safe taste memory trace (ST) but spared consolidation of conditioned taste aversion (CTA). Conversely, blocking Arc synthesis within the AMY impaired CTA consolidation but had no effect on ST long-term memory formation. Our results suggest that Arc-dependent plasticity during taste learning is required within distinct structures of the medial temporal lobe, depending on the emotional valence of the memory trace. es_MX
dc.format application/pdf es_MX
dc.identificador.materia 3 es_MX
dc.identifier.uri http://hdl.handle.net/20.500.12222/332
dc.language eng es_MX
dc.publisher Science Direct es_MX
dc.publisher Elsevier es_MX
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights.license info:eu-repo/semantics/openAccess es_MX
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ es_MX
dc.source.other Behavioural Brain Research. Vol.342 (2018) es_MX
dc.source.other ISSN: 0166-4328 es_MX
dc.subject MEDICINA Y CIENCIAS DE LA SALUD es_MX
dc.subject.keywords Conditioned taste aversion es_MX
dc.subject.keywords Safe taste memory es_MX
dc.subject.keywords Insular cortex es_MX
dc.subject.keywords Amygdala es_MX
dc.subject.keywords Activity regulated cytoskeletal-associated es_MX
dc.subject.keywords Protein es_MX
dc.title Differential requirement of de novo Arc protein synthesis in the insular cortex and the amygdala for safe and aversive taste long-term memory formation es_MX
dc.type conferencePaper es_MX
dc.type.uri https://doi.org/10.1016/j.bbr.2018.01.006 es_MX
dc.type.version info:eu-repo/semantics/publishedVersion es_MX
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